Clinical Study of an Anti-Cellulite Cosmetics Containing Solubilized System of Poorly Soluble Caffeine and a Skin Penetrating Peptide

Authors

  • Su In Park
  • Soo Hyeon Heo
  • Moon Sam Shin

Abstract

The aim of the study was to determine the clinical efficacy and safety on anti-cellulite cosmetics containing solubilized system (12.0% caffeine; 8.0% mixed hydrotropes; niacinamide and vanillin) of poorly soluble caffeine and a transdermal penetrating peptide (100ppm arginine oligomer peptide, R6). Dermal and subcutaneous lipid interface length measurement, skin roughness measurement, researcher visual assessment and thigh normal photo shoot were used. This study was conducted on 23 adult females with cellulite skin aged 20~50 years. A total of 23 subjects who met the criteria for selection and who did not meet the exclusion criteria and who were consenting to participate in the human body test were used for 6 weeks at the designated site. Clinical results was summarized as followed: 1) the dermis and subcutaneous lipid interface length was statistically significantly decreased after 3 and 6 weeks using the product (p<0.05); 2) the skin roughness value of the thigh was statistically significantly decreased 3 and 6 weeks (p<0.05); 3) the cellulite grades of researcher’s visual evaluation in the thigh area were statistically decreased (p<0.025) after 6 weeks; 4) subjective questionnaire evaluation scores increased significantly (p<0.025) after 3 and 6 weeks; 5) There was no skin adverse event reported after using the product during the study period. Therefore, the test containing a caffeine complex and a skin penetrating peptide is have beneficial effects in reducing the temporary cellulite in the thigh for 6 weeks. 

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Published

2019-12-12

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Section

Articles